X-ray crystallographic studies of leukemia inhibitory factor
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چکیده
منابع مشابه
X-ray crystallographic studies on murine nerve growth factor.
The largest and best characterised family of neurotrophic growth factors is that of nerve growth factor (NGF) and its relatives. In order to understand the relation of structure and function, we have undertaken X-ray analyses of murine NGF. The active component beta-NGF crystallises as hexagonal bipyramids that give good X-ray diffraction data using a synchrotron to 2.3A resolution. We have pre...
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Leukemia inhibitory factor (LIF) is a polyfunctional molecule with significant and diverse biological activities. LIF is a glycoprotein secreted by a number of different cell types in vitro. It is induced in fibroblasts, lymphocytes, monocytes and astrocytes by various inducers such as serum, TNF, interleukin-IP and EGF. Due to extensive and variable glycosylation the molecular weight can range...
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X-ray diffraction (XRD) studies are very usefu l for distinguishing crystalline and non-crystalline states. Highl y crystal line substances give patterns with sharp diffraction peaks or spots, whereas liquids or amorphous material s lie between these two extremes, because their chain length is large and it is difficult to attain three-dimensional regularity. However, XRD stud ies of polymers yi...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 1993
ISSN: 0108-7673
DOI: 10.1107/s0108767378096750